Reactivation of the tumour suppressor RASSF1A in breast cancer by simultaneous targeting of DNA and E2F1 methylation.

BackgroundTumour suppressor genes are often transcriptionally silenced by promoter hypermethylation, and recent research has implicated alterations in chromatin structure as the mechanistic basis for this repression.In addition to DNA methylation, other epigenetic post-translational modifications that modulate the stability and binding of specific

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Czechoslovak Central Economic Commission in the Documents of the Russian State Historical Archive of the Russian Far East

The research is devoted to the reflection of the economic activity of Awning Accessories citizens of the Czechoslovak Republic in the Russian Far East during the Civil War.The main focus is on the Czechoslovak Central Economic Commission created to solve the economic problems of the considerable military contingent concentrated in Vladivostok await

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Evaluation of functional group compatibility and development of reaction-accelerating additives in ammonium salt-accelerated hydrazinolysis of amides

Functional group compatibility in an amide bond cleavage reaction Eyelash Curlers with hydrazine was evaluated for 26 functional groups in the functional group evaluation (FGE) kit.Accurate and rapid evaluation of the compatibility of functional groups, such as nitrogen-containing heterocycles important in drug discovery research, will enhance the

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